A new window on c-Myb function.

include defects of DNA repair that carry a well-defined risk of transformation due to genomic instability, not just a lack of effective immune surveillance.10 Nonetheless, the study by Vajdic et al demonstrates the power of linking data derived from population-based and diseasespecific registries to gain insights into the pathophysiology of cancer. With the development of PID registries in many areas of the world, the findings of this study are expected to be confirmed or challenged. Regional differences in the incidence of cancer among patients with PID might also emerge because of the distribution variability of various types of PID, exposure to tumorpromoting pathogens, and frequency of genetic variants conferring cancer susceptibility among different populations. Conflict-of-interest disclosure: The author declares no competing financial interests. ■